Work

Additional Antibiotic Inhibitors of Peptidoglycan Synthesis

Year: 1973

Type: article

Abstract: Diumycin, janiemycin, nisin, and subtilin inhibited peptidoglycan synthesis catalyzed by particulate enzyme systems from Bacillus stearothermophilus and Escherichia coli. All of these, except for nisin, also induced accumulation of the lipid intermediate in peptidoglycan synthesis. Concentrations required for 50% inhibition of peptidoglycan synthesis were less than 0.1 mug/ml for diumycin and in the range of 10 to 100 mug/ml for janiemycin, nisin, and subtilin in both organisms. The discrepancy between the extremely low concentration of diumycin required to inhibit the in vitro system from E. coli and the much higher concentration required to inhibit growth of the organism is noteworthy.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.4.3.231

Authors: Paul E. Linnett, Jack L. Strominger

Institution: Harvard University

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institute of Allergy and Infectious Diseases

OpenAlex ID: W2106358697

FWCI: 1.254

Cites: 32

Cited by: 91

Related to: 10