Work

S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis

Year: 2012

Type: article

Abstract: NMDA receptor activation can elicit synaptic plasticity by augmenting conductance of the AMPA receptor GluA1 subsequent to phosphorylation at S831 by Ca(2+)-dependent kinases. NMDA receptor activation also regulates synaptic plasticity by causing endocytosis of AMPA receptor GluA1. We demonstrate a unique signaling cascade for these processes mediated by NMDA receptor-dependent NO formation and GluA1 S-nitrosylation. Thus, S-nitrosylation of GluA1 at C875 enhances S831 phosphorylation, facilitates the associated AMPA receptor conductance increase, and results in endocytosis by increasing receptor binding to the AP2 protein of the endocytotic machinery.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.1221295110

Authors: Balakrishnan Selvakumar, Meagan A. Jenkins, Natasha K. Hussain, Richard L. Huganir, Stephen F. Traynelis, Solomon H. Snyder

Institutions: Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine, Emory University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze

Funders: Howard Hughes Medical Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke