Work

Electrophysiological correlates of the brain's intrinsic large-scale functional architecture

Year: 2008

Type: article

Abstract: Spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signals demonstrate consistent temporal correlations within large-scale brain networks associated with different functions. The neurophysiological correlates of this phenomenon remain elusive. Here, we show in humans that the slow cortical potentials recorded by electrocorticography demonstrate a correlation structure similar to that of spontaneous BOLD fluctuations across wakefulness, slow-wave sleep, and rapid-eye-movement sleep. Gamma frequency power also showed a similar correlation structure but only during wakefulness and rapid-eye-movement sleep. Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0807010105

Authors: Biyu J. He, Abraham Z. Snyder, John M. Zempel, Matthew D. Smyth, Marcus E. Raichle

Institution: Washington University in St. Louis

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: Brain and its Vasculature, G861322675, G9000036150