Work

No Effect of Exercise on Urinary 6-Sulfatoxymelatonin and Catecholamines in Young Women Participating in a 16-Week Randomized Controlled Trial

Year: 2013

Type: article

Abstract: BACKGROUND: Women with breast cancer have decreased levels of melatonin or its metabolite in plasma and/or urine. METHODS: We measured serum melatonin, urinary 6-sulfatoxymelatonin, catecholamines, and cortisol in 141 sedentary young female participants in a clinical trial comparing 150 min/wk aerobic exercise for 4 months to no-exercise controls. Demographics, health surveys, body composition, sleep quality, fitness levels, and blood and urine samples were obtained at baseline and 16 weeks. RESULTS: There were no differences between groups at baseline in demographics, exercise, sleep habits, or study hormones. There were also no significant differences between groups in any of the hormones at 16 weeks. CONCLUSION: Sixteen weeks of exercise had minimal effects on melatonin secretion of young women. IMPACT: There is convincing evidence that exercise protects against breast cancer, but this does not appear to occur through changes in melatonin secretion.

Source: Cancer Epidemiology Biomarkers & Prevention

DOI: 10.1158/1055-9965.epi-13-0583

Authors: Andrea Y. Arikawa, William Thomas, Sanjay R. Patel, Mindy S. Kurzer

Institutions: Brigham and Women's Hospital, University of Minnesota

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Center for Research Resources