Work

Structural and functional changes in high-density lipoprotein induced by chemical modification

Year: 2015

Type: article

Abstract: Reconstituted high-density lipoprotein (rHDL), a natural nanoparticle consisting of apolipoprotein A-I and phospholipids, was modified with a hydrophobic fluorescent dye before (pre-rHDL) and after (post-rHDL) reconstitution. Pre-rHDL particles had a similar size to unmodified rHDL, but post-rHDL particles were significantly larger and their avidity for a HDL receptor was 2.6 times of that shown by pre-rHDL.

Source: Biomaterials Science

DOI: 10.1039/c4bm00402g

Authors: Tatsuya Murakami, Haruki Okamoto, Hyungjin Kim

Institution: Kyoto University

Language: English

Topic: Cholesterol and Lipid Metabolism

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science