Neurobiological underpinnings of suicidal behavior: Integrating data from clinical and biological studies
Year: 2009
Type: article
Abstract: Background and Objectives: Every year, suicide accounts for approximately one million preventable deaths worldwide.Suicidal behavior is complex and multi-determined with risk factors identified in multiple domains including clinical, genetic, environmental, behavioral, neurophysiological, and neurocognitive.Modeling causal pathways that integrate these factors may assist in better identification of high-risk individuals would allow for effective preventive intervention.Methods: Published literature in the English language was reviewed to identify evidence supporting a multi-dimensional model of putative causal pathways for suicidal behavior.Results: There is evidence that clinical, neurochemical, neuroendocrine, neurocognitive, and neurophysiological contributory factors may be useful as intermediate phenotypes in describing putative causal pathways from genetics and early-life adversity to suicidal acts.Conclusions: Determining the causes of suicidal behavior involves integrating risk factors from multiple domains.
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $1,910
OpenAlex ID: W2106602192