Work

Dysregulation of Diverse Ion Transport Pathways Controlling Cell Volume Homoestasis Contribute to Neuroglial Cell Injury Following Ischemic Stroke

Year: 2014

Type: editorial

Abstract: gives readers a timely update on the emerging roles of gluta-mate receptor-independent ion channels and transporters in ischemic brain injury. This issue has collected contributions from the leading research laboratories with expertise on the most important ion transport targets. For example, Khanna et al. [1] provide an overview on the significance of dysreg-ulated ion homeostasis in the neurogliovascular unit in the pathogenesis of ischemic cerebral edema, focusing on the role of the sulfonylurea receptor 1-transient receptor potential melastatin 4 (SUR1-TRPM4) channel complex which is up-regulated in the context of hypoxia and promotes capillary fragmentation and oncotic cell death in the vascular endothe-lium, thereby increasing vascular permeability and vasogenic edema. Song et al. write an elegant review on the distinct changes of cell volume homeostasis in necrotic, apoptotic, and

Source: Translational Stroke Research

DOI: 10.1007/s12975-014-0324-3

Authors: Dandan Sun, Kristopher T. Kahle

Institutions: University of Pittsburgh, Boston Children's Hospital, Harvard University, Massachusetts General Hospital, Manton Center for Orphan Disease Research

Language: English

Topic: Ion Transport and Channel Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,490