Optimization of In - vitro Permeation Pattern of Ketorolac Tromethamine Transdermal Patches.
Year: 2011
Type: article
Abstract: The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surfacet opography of the patches was examined by scanning electron microscopy (SEM). The drug-polymer interaction studies were performed using Fourier transform infrared spectroscopic (FTIR) technique. A correlation between in - vitro drug-release and in - vitro skin permeation was established and the criterion of desirability was employed to optimize the formulation. The results of the physicochemical characterization and in - vitro permeation of the prepared patches were promising to formulate transdermal patches with PVP/EC combinations.
Source: Europe PMC (PubMed Central)
Authors: Pintu Kumar De, Subrata Mallick, Biswajit Mukherjee, Sagar Sengupta, Satyanarayan Pattnaik, Subrata Chakraborty
Institutions: Siksha O Anusandhan University, Jadavpur University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2106827058