Get started
Work

Changes in Cholesterol-Lowering Medications Use Over a Decade in Community-Dwelling Older Adults

Year: 2013
Type: article
Abstract: BACKGROUND: The impact of evidence-based guidelines and controlled trial data on use of cholesterol-lowering medications in older adults is unclear. OBJECTIVE: To examine whether utilization patterns of cholesterol-lowering medications in community-dwelling older adults changed following the release of the National Cholesterol Education Program Adult Treatment Panel III guidelines and results from the Prospective Study of Pravastatin in the Elderly at Risk in 2002. METHODS: Community-dwelling elderly individuals who were enrolled in the Health, Aging and Body Composition Study in 1997-1998 were followed for up to 11 years. An interrupted time series analysis with multivariable generalized estimating equations (GEEs) was used to examine changes in level and trend in cholesterol-lowering medication use before and after 2002, adjusting for sociodemographics, health-related behaviors, and health status. RESULTS: Cholesterol-lowering medication use increased nearly 3-fold from 14.9% in 1997-1998 to 42.6% in 2007-2008, with statins representing the most common class used (87-94%). Multivariable GEE results revealed no significant difference in the level of cholesterol-lowering medication use after 2002 (adjusted OR 0.95; 95% CI 0.89-1.02). Multivariable GEE results revealed that trend changes in the rate of increase in cholesterol-lowering medication declined after 2002 (adjusted ratio of ORs 0.92; 95% CI 0.89-0.95). CONCLUSIONS: The use of cholesterol-lowering medication increased substantially over a decade in community-dwelling elderly individuals but was not related to a change in level or trend following the release of the guidelines and evidence-based data.
DOI: 10.1345/aph.1s050
Authors: Wei-Hsuan Lo-Ciganic, Robert M Boudreau, Shelly L Gray, Janice C Zgibor, Julie M Donohue, Subashan Perera, Anne B Newman, Eleanor M Simonsick, Douglas C Bauer, Suzanne Satterfield, Joseph T Hanlon
Institutions: University of Pittsburgh, University of Washington, National Institutes of Health, National Institute on Aging, University of California, San Francisco, University of Tennessee Health Science Center, Geriatric Research Education and Clinical Center, VA Pittsburgh Healthcare System
Language: English
Subfield: Surgery
Field: Medicine
Open Access status: green
Awards: G100949702, Peripheral nerve decline: an underappreciated cause of injurious falls, Longitudinal Impact of Antihypertensive Polypharmacy on Geriatric Syndromes, Intervention to Reduce Dietary Sodium in Hemodialysis, IMPACT OF MEDICARE PART D ON RACIAL DISPARITIES IN DIABETES TREATMENT AND OUTCOME, G2741792843, G405217353, G405715915, G5743784024, G640327682, End of Life in the Very Old, G670738241, G692659954, G710829228, THE UNIVERSITY OF PITTSBURGH'S COMPARATIVE EFFECTIVENESS RESEARCH SCHOLARS PROGRA, ENHANCING THE DETECTION AND MANAGEMENT OF ADVERSE DRUG EVENTS IN THE NURSING HOME, UPITT Program for Pharmaceutical Outcomes Research in Aging, G861947890, G88327988, Pittsburgh Older Americans Independence Center
OpenAlex ID: W2106859384
FWCI: 1.496
Cites: 64
Cited by: 14
Related to: 10