Year: 2003
Type: editorial
Abstract: Mendelian Forms of Human Hypertension and Mechanisms of Disease" nicely outlines diagnostic clues to aid the practitioner in the recognition of monogenic forms of hypertension in clinical practice.This paper identifies a series of six causative genes for well-defined genetic syndromes that act at different steps of the renin angiotensin system.His paper stresses the importance of obtaining a family history for clues about associated conditions (Neurofibromatosis Type 1, Von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2) in other family members and noting early ages of onset of hypertension in affected individuals.This would raise suspicion that a patient's hypertension may have a single allele genetic basis and indicate the need for a physical examination to identify phenotypic abnormalities.
Source: Clinical Medicine & Research
DOI: 10.3121/cmr.1.4.271
Author: P. F. Giampietro
Institutions: Marshfield Clinic, Marshfield Clinic, Marshfield Clinic
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2106897830