Year: 2011
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: BACKGROUND: Several genome scans have explored the linkage of chronic kidney disease phenotypes to chromosomic regions with disparate results. Genome scan meta-analysis (GSMA) is a quantitative method to synthesize linkage results from independent studies and assess their concordance. METHODS: We searched PubMed to identify genome linkage analyses of renal function traits in humans, such as estimated glomerular filtration rate (GFR), albuminuria, serum creatinine concentration and creatinine clearance. We contacted authors for numerical data and extracted information from individual studies. We applied the GSMA nonparametric approach to combine results across 14 linkage studies for GFR, 11 linkage studies for albumin creatinine ratio, 11 linkage studies for serum creatinine and 4 linkage studies for creatinine clearance. RESULTS: No chromosomal region reached genome-wide statistical significance in the main analysis which included all scans under each phenotype; however, regions on Chromosomes 7, 10 and 16 reached suggestive significance for linkage to two or more phenotypes. Subgroup analyses by disease status or ethnicity did not yield additional information. CONCLUSIONS: While heterogeneity across populations, methodologies and study designs likely explain this lack of agreement, it is possible that linkage scan methodologies lack the resolution for investigating complex traits. Combining family-based linkage studies with genome-wide association studies may be a powerful approach to detect private mutations contributing to complex renal phenotypes.
DOI: 10.1093/ndt/gfr255
Institutions: Tufts University, Tufts Medical Center, University of North Carolina at Chapel Hill, Texas Biomedical Research Institute, Georgetown University, Georgetown University Medical Center, Wake Forest University Health Sciences, Wake Forest University, National Heart, Lung, and Blood Institute, Framingham Heart Study, Boston University, Case Western Reserve University, University of Utah
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: Wake Forest University, Johns Hopkins University, Case Western Reserve University, National Institutes of Health, University of California, Irvine, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: HYPERGEN, Case FIND Participating Investigative Center, University of New Mexico Clinical and Translational Science Center, G1272326107, G1374583558, General Clinical Research Center, G1730664372, IDENTIFICATION OF DIABETIC NEPHROPATHY RISK GENES, G1881788261, G1910965489, G1946071602, G203315901, The Genetic Basis of Diabetic Retinopathy in Mexican Am*, G2081319657, G2215790005, G250621538, G2549691667, G2711771904, G284047611, HYPERGEN, HYPERGEN - BIRMINGHAM FIELD CENTER, HYPERGEN-BOSTON UNIVERSITY/FRAMINGHAM FIELD CENTER, MALD FIND Renewal, G3042145041, GENOTYPING FOR LOCATING HUMAN DISEASE GENES, UNM HSC Clinical and Translational Science Center, HYPERGEN- DATA COORDINATING CENTER, NHLBI FAMILY BLOOD PRESSURE PROGRAM-HYPERGEN-MPLS FC, HYPERGEN, GENERAL CLINICAL RESEARCH CENTER, G3707580291, Mapping Genes for NIDDM Nephropathy in African Americans, The Family Blood Pressure Program (HyperGEN Network), TGF-beta1 and PAI-1 genotypes in Chronic Kidney Disease, G5108863858, G5164707915, G5359555627, An Integrative Genomic Approach to APOL1-Associated Nephropathy., HYPERGEN, G5780424650, Tufts Clinical and Translation Science Institute (UL1), University of New Mexico - General Clinical Research Center, G6170042502, HYPERGEN CENTRAL BIOCHEMISTRY LABORATORY, Linkage Consortium End-Stage-Renal Disease, G6360247786, GENETIC ANALYSIS OF HUMAN HYPERTENSIVE ESRD, The Framingham Heart Study, Continuation of the FIND Study, HYPERGEN-NC, G6617052721, Natural History of MYH9-Associated Nephropathy, General Clinical Research Center, ZUNI KIDNEY PROJECT - FAMILY STUDIES, The Family Blood Pressure Program (Program Data Center), General Clinical Research Center, GENETIC DETERMINANTS OF HIGH BLOOD PRESSURE, HYPERGEN, Genetics of Diabetic Nephropathy in Mexican-Americans a*, GENETIC EPIDEMIOLOGY OF AGING IN UTAH PEDIGREES, HyperGEN: Genetics of Left Ventricular Hypertrophy, General Clinical Research Center, G9000010577, G9000036580, G9000038356, G9000099276, G9000102603, G9000117211, G9000124674, G9000237528, G9000321596, G9000331617, HYPERGEN
OpenAlex ID: W2106907719