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Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene

Year: 2006

Type: article

Abstract: Telomerase, the enzyme that elongates our telomeres, is crucial for cancer development based on extensive analyses of human cells, human cancers, and mouse models. New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MDV), an oncogenic herpesvirus of chickens, promotes tumor formation. These findings highlight the importance of telomerase in cancer and raise new questions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20060849

Author: Steven E. Artandi

Institutions: Stanford Medicine, Stanford University

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2106916409