Work

Chemokines in colitis: microRNA control

Year: 2013

Type: article

Abstract: Huang et al1 identified and tested the role of a specific microRNA (miRNA) in the pathogenesis of IBD. The study of microRNAs is a burgeoning field within epigenetics. These small non-coding RNAs mediate translation-level repression of protein expression by binding to the 30-untranslated region of specific messenger RNA transcripts. In the innate and adaptive immune response, miRNAs play an import-ant role in negative regulation of inflamma-tory conditions in the intestine. Inflammatory regulators such as IL-6, tumor necrosis factor (TNF) and toll-like receptors have been shown to induce miRNA expression in both acute and

Source: Gut

DOI: 10.1136/gutjnl-2013-305886

Authors: Ishan Roy, Christopher T Veldkamp, Brian F Volkman, Michael B Dwinell

Institutions: Medical College of Wisconsin, University of Wisconsin–Whitewater

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases