53BP1: function and mechanisms of focal recruitment
Year: 2009
Type: review
Abstract: 53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of 53BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.
Source: Biochemical Society Transactions
DOI: 10.1042/bst0370897
Institution: Ollscoil na Gaillimhe – University of Galway
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2107029023