Work

Response to Iron Deprivation in Saccharomyces cerevisiae

Year: 2007

Type: review

Abstract: Iron is an essential nutrient for almost every organism because iron cofactors, such as heme and iron-sulfur clusters (ISC), are required for the activity of numerous cellular enzymes involved in a wide range of cellular processes. Although iron is a very abundant metal in the earth’s crust, it has a low bioavailability. In aerobic environments, iron is largely present in the oxidized, ferric form, which is poorly soluble at neutral pH. Thus, iron can be limiting for growth, and single-celled organisms and plants have evolved sophisticated strategies for acquiring iron from the environment. In humans, iron is absorbed poorly from the diet, especially if the diet is entirely plant based and low in ascorbic acid. Iron deficiency is the most common nutritional deficiency in the world and is a significant public health problem, especially among children and women of childbearing age (68). The most obvious manifestation of

Source: Eukaryotic Cell

DOI: 10.1128/ec.00354-07

Authors: Caroline C. Philpott, Olga Protchenko

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Fungal and yeast genetics research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDGs: Zero hunger, Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases