Year: 1993
Type: dissertation
Abstract: The research presented in this thesis addresses the above mentioned issue\non the basis of four psychophysiological experiments. These experiments were\naimed at separately manipulating concentrations of circulating adrenaline and\nnoradrenaline by means of infusions of catecholamines, pharmacological\ninterventions, or psychological (mental stress) challenges in healthy subjects,\nduring studies of the effects on cardiovascular activity and subjective mood. In\nparticular, the dynamics of the cardiovascular system were evaluated in relation\nto circulating noradrenaline and adrenaline by employing the method of spectral\nanalysis of haemodynamic variables. In order to increase our understanding of\nthe metabolism and renal excretion of catecholamines, special attention was paid\nto urinary catecholamine metabolites, in relation to altered plasma catecholamine\nconcentrations.\n\nIn the experiments presented in this thesis, plasma catecholamine concentrations\nwere manipulated by means of pharmacological and psychological challenges.\nThe subjects participating in the studies were healthy young male volunteers,\nrecruited by means of advertisements. All volunteers were subjected to a\nmedical, psychiatric and psychological screening to exclude abnormalities in\nphysical and mental health. Careful attention was paid to the control of\nconfounding factors such as posture, food intake, smoking, and drinking.\nWhere appropriate, endocrine and metabolic parameters were monitored in\norder to control for the possible effects of our manipulations on these\nparameters
Author: J.H.M. Tulen
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2107425799