Early clinical cancer trials: Proof of concept and beyond
Year: 2011
Type: dissertation
Abstract: Over the last few decades clinical cancer research has developed at accelerating speed,\\nresulting in a tremendous increase of knowledge with regard to tumour biology, hypotheses\\nto interfere with tumour growth and the subsequent development of anticancer therapies.\\nObviously, the ultimate aim of cancer research is to identify treatment approaches\\nimproving overall survival with a good quality of life. Novel anticancer therapies mostly\\narise from scientifi c insights in preclinical studies, and provided that they have looked\\npromising in vitro and in animal models, at one point they have to be tested in humans.\\nTesting new cancer therapies in patients occurs in diff erent stages, i.e. successively in phase\\nI, phase II and phase III trials.
Author: Inge R. Konings
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2107445688