Work

Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography

Year: 2009

Type: article

Abstract: Plasmon-resonant gold nanorods (GNRs) can serve as imaging agents for spectroscopic optical coherence tomography (SOCT). The aspect ratio of the GNRs are adjusted for maximum absorption in the far red to create a partial spectral overlap with the low-wavelength edge of the near-infrared SOCT imaging band. The spectroscopic absorption profile of the GNRs is incorporated into a depth-resolved algorithm for mapping the relative GNR density within OCT images. This technique enables us to image GNR distributions in excised human breast carcinomas, demonstrating their potential as OCT contrast agents in heteregeneous, highly scattering tissues.

Source: Journal of Materials Chemistry

DOI: 10.1039/b823389f

Authors: Amy L. Oldenburg, Matthew N. Hansen, Tyler S. Ralston, Alexander Wei, Stephen A. Boppart

Institutions: University of Illinois Urbana-Champaign, Purdue University West Lafayette

Language: English

Topic: Optical Coherence Tomography Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green