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Intracellular Casp8p41 Content Is Inversely Associated with CD4 T Cell Count

Year: 2010
Type: article
Study design: Observational Study
Abstract: Casp8p41 is a protein fragment generated by cleavage of procaspase 8 by human immunodeficiency virus (HIV) protease. We measured Casp8p41 content in memory CD4 T cells and analyzed the association of Casp8p41 content with CD4 T cell count, cross-sectionally and longitudinally. Casp8p41 content was inversely correlated with CD4 T cell count, and change in Casp8p41 content was associated with absolute CD4 T cell count with change over time. Casp8p41 change was a better predictor of CD4 T cell count change than activated CD8 T cell percentage or viral load and was comparable to bacterial 16s DNA levels. This suggests that Casp8p41 is a relevant mediator of CD4 T cell death during HIV infection.
DOI: 10.1086/653705
Authors: Nathan W. Cummins, Wei Jiang, John McGinty, Gary D. Bren, Ronald J. Bosch, Alan Landay, Steven G. Deeks, Jeffrey N. Martin, Daniel Douek, Michael M. Lederman, Jason Brenchley, Andrew D. Badley
Institutions: Mayo Clinic, Case Western Reserve University, Harvard University, Rush University Medical Center, University of California, San Francisco, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Vaccine Research Center
Language: English
Subfield: Virology
Open Access status: bronze
Funders: National Institutes of Health, U.S. Public Health Service, Center for AIDS Research, University of Washington, University of California, San Francisco, National Institute of Mental Health, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources
Awards: G1116104148, Regulation of HIV-Mediated CD4 T Cell Apoptosis, G1425538986, Clinical and Translational Science Institute, Impact of HIV-associated inflammation on disease, G1819583291, Kidney Disease Research Training Program, UCSF-GIVI CENTER FOR AIDS RESEARCH, G200995756, G2084067272, G3322721267, G374818150, G3810609436, G3873853564, G4522520631, G4553935269, Case Clinical Trials Unit, Regulation of HIV-Mediated CD4 T Cell Apoptosis, G5418282550, G6049565824, Case AIDS Clinical Trials Unit, G650174051, G6910394198, G758528517, G7645049137, G9000020842, G9000039438, G9000058261, G9000103698, G9000173233, G9000176126, G9000273641, G9000292181, Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, G97119092
OpenAlex ID: W2107590795
FWCI: 0.316
Cites: 15
Cited by: 13
Related to: 10