Work

Interleukin-1 Receptor Antagonist Gene Polymorphism and Circulating Levels of Human Immunodeficiency Virus Type 1 RNA in Brazilian Women

Year: 2001

Type: article

Abstract: Interleukin-1 receptor antagonist (IL-1ra) gene polymorphisms in 83 human immunodeficiency virus (HIV)-seropositive women were evaluated. Fourteen of the subjects (16.9%) were homozygous for IL-1ra allele 2 (IL-1RN*2). These women had a lower median level of HIV RNA than did women homozygous for allele 1 (IL-1RN*1) (P = 0.01) or heterozygous for both alleles (P = 0.04). Among 46 subjects not receiving antiretroviral treatment, HIV levels were also reduced in IL-1RN*2 homozygous individuals (P < 0.05). There was no relation between IL-1ra alleles and CD4 levels.

Source: Journal of Virology

DOI: 10.1128/jvi.75.13.6242-6244.2001

Authors: Steven S. Witkin, Iara M. Linhares, Stefan Gerber, Marie E. Caetano, Alusio C. Segurado

Institutions: Cornell University, Weill Cornell Medicine, Universidade de São Paulo

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2107670642

FWCI: 0.696

Cites: 23

Cited by: 19

Related to: 10