Work

A Left‐Handed Solution to Peptide Inhibition of the p53–MDM2 Interaction

Year: 2010

Type: article

Abstract: Throwing tumors a left-hook punch: The oncoprotein MDM2 negatively regulates the activity and stability of the tumor suppressor protein p53, and is an important molecular target for anticancer therapy. Mirror-image phage display identified a high-affinity D-peptide ligand of MDM2 (see structure) that could be developed into a potent and protease-resistant p53 activator with potential antitumor activity.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201000329

Authors: Min Liu, Marzena Pazgier, Changqing Li, Weirong Yuan, Chong Li, Wuyuan Lu

Institutions: University of Maryland, Baltimore, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University

Language: English

Topic: Cancer-related Molecular Pathways

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Allergy and Infectious Diseases