The Next PAGE in Understanding Complex Traits: Design for the Analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study
Year: 2011
Type: article
Study design: Study Protocol
Abstract: Genetic studies have identified thousands of variants associated with complex traits. However, most association studies are limited to populations of European descent and a single phenotype. The Population Architecture using Genomics and Epidemiology (PAGE) Study was initiated in 2008 by the National Human Genome Research Institute to investigate the epidemiologic architecture of well-replicated genetic variants associated with complex diseases in several large, ethnically diverse population-based studies. Combining DNA samples and hundreds of phenotypes from multiple cohorts, PAGE is well-suited to address generalization of associations and variability of effects in diverse populations; identify genetic and environmental modifiers; evaluate disease subtypes, intermediate phenotypes, and biomarkers; and investigate associations with novel phenotypes. PAGE investigators harmonize phenotypes across studies where possible and perform coordinated cohort-specific analyses and meta-analyses. PAGE researchers are genotyping thousands of genetic variants in up to 121,000 DNA samples from African-American, white, Hispanic/Latino, Asian/Pacific Islander, and American Indian participants. Initial analyses will focus on single nucleotide polymorphisms (SNPs) associated with obesity, lipids, cardiovascular disease, type 2 diabetes, inflammation, various cancers, and related biomarkers. PAGE SNPs are also assessed for pleiotropy using the "phenome-wide association study" approach, testing each SNP for associations with hundreds of phenotypes. PAGE data will be deposited into the National Center for Biotechnology Information's Database of Genotypes and Phenotypes and made available via a custom browser.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwr160
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,856
Funders: University of Southern California, Vanderbilt University, Strong, National Institutes of Health, University of North Carolina at Chapel Hill, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources
Awards: CARDIA, G1081972346, Cardiovascular Disease in Sioux Indians, Women's Health Initiative, G118440752, G1220223050, G1241292848, G1312369436, Epidemiology of putative genuine genetic variant: The Women's Health Intiative, G1325221871, Women's Health Initiative, G136105103, Hispanic Community Health Study, G1455175283, G1462415530, CHS-ULTRASOUND READING, G153510172, CARDIA, The Strong Heart Study, Phase V, G1548097448, Women's Health Initiative, CORONARY HEART DISEASE AND STROKE, G1639455850, G164614106, MRI READING CENTER FOR THE CARDIOVASCULAR HEALTH STUDY, G1666450717, CARDIA, G191650467, Atherosclerosis Risk in Communities Study (ARIC), Women's Health Initiative, CARDIA-ECHOCARDIOGRAPHY READING, G215333750, G2194386449, Epidemiology of Putative Causal Variants in the Multiethnic Cohort, G2466919156, HISPANIC COMMUNITY HEALTH STUDY - FIELD CENTER, CARDIA, CCSP FIELD CENTER, G2528054427, G25881238, G2644289446, COMMUNITY AND COHORT SURVEILLANCE PROGRAM, G277826483, G2786045897, CENTRAL HEMOSTATIS LABORATORY FOR CCSP, Strong Heart Family Study, G2970637568, WGA Study to Identify Genetic Variants Associated with CV Events in CHS, G305513510, LONGITUDINAL STUDIES OF CORONARY HEART DISEASE RISK FACTORS IN YOUNG ADULTS, G3107571658, Cardiovascular Evaluation for the SHS Phase V, CORONARY ARTERY DISEASE RISK DEVELOPMENT IN YOUNG ADULTS, G3191277318, G3226848658, G3236609591, G328935669, Hispanic Community Health Study, Women's Health Initiative Memory Study (WHIMS), G3396487927, Women's Health Initiative, Multiethnic Cohort Study of Diet and Cancer, G390162502, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, Women's Health Initiative, G4048755144, Women's Health Initiative, NHGRI EpiGenVar Coordinating Center, G413560588, G4165892905, G423252844, Coronary Artery Risk Development in Young Adults (CARDIA) Study - Field Center, G4289235060, COORDINATING CENTER FOR WOMEN'S HEALTH INITIATIVE, G429396632, Hispanic Community Health Study, G445374210, Atherosclerosis Risk in Communities Study (ARIC), G50822097, G510023084, G5232982263, FOR ALL FIELD CENTER FOR WHI EXTENSION, G528395701, G5365244667, HISPANIC COMMUNITY HEALTH STUDY - COORDINATING CENTER, G5451084504, G5452216648, Atherosclerosis Risk in Communities Study (ARIC), G582705428, G589878898, CHS Events Follow-up Study, G6075306088, G6203107232, G6226795708, Characterizing Genetic Susceptibility to Breast and Prostate Cancer; the BPC3, G6520056932, G6557431990, CHS-Transition Phase, Women's Health Initiative, G6918065631, G715477388, G7223985928, Women's Health Initiative, CHS RETINAL READING CENTER, General Clinical Research Center, CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY, G786153652, Genetic Epidemiology of Causal Variants Across the Life Course, Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study, G793702358, G7999488110, G812579647, A Genome-wide Association Study of Prostate Cancer in African Americans, Epidemiologic Architecture for Genes Linked to Environment (EAGLE), G8486527673, G8593276544, G863538970, Cardiovascular Disease in Pima Indians, G9000002220, G9000015938, G9000016408, G9000029166, G9000072420, G9000099044, G9000151586, G9000284018, Diabetes Research Center (DRC), G939135972, Atherosclerosis Risk in Communities Study (ARIC)
OpenAlex ID: W2107862628