Work

ChIPOTle: a user-friendly tool for the analysis of ChIP-chip data

Year: 2005

Type: article

Abstract: ChIPOTle (Chromatin ImmunoPrecipitation On Tiled arrays) takes advantage of two unique properties of ChIP-chip data: the single-tailed nature of the data, caused by specific enrichment but not specific depletion of genomic fragments; and the predictable enrichment of DNA fragments adjacent to sites of direct protein-DNA interaction. Implemented as a Microsoft Excel macro written in Visual Basic, ChIPOTle uses a sliding window approach that yields improvements in the identification of bona fide sites of protein-DNA interaction.

Source: Genome biology

DOI: 10.1186/gb-2005-6-11-r97

Authors: Michael J Buck, Andrew B Nobel, Jason D Lieb

Institution: University of North Carolina at Chapel Hill

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $5,490

Funders: National Science Foundation, National Institutes of Health, National Human Genome Research Institute, National Institute of General Medical Sciences