The haploimmunostorm syndrome: A distinct clinical entity seen in HLA-mismatched cellular immunotherapy
Year: 2005
Type: article
Abstract: We have observed a new infusion related clinical entity named haploimmunostorm (HIS), observed after minimal immunosuppressive HLA-3/6 or 4/6 mismatched stem cell transplantation. We have performed a total of 44 HLA-mismatched transplants with escalation of the CD3+ dose from 1 × 106-2 × 108 cells/kg using G-CSF primed PBSC, with a conditioning regimen of 100 cGy TBI. The CD34+ dose was >2 × 106 cells/kg. This post-infusion HIS syndrome occurred in 26 out of 30 (87%) patients with a CD3+ dose more than 1 × 108 cells/kg.
Institutions: Roger Williams Medical Center, Massachusetts General Hospital
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2107879345