Year: 2008
Type: article
Abstract: A plethora of new regulatory T cell (Treg) mechanisms have recently emerged. This raises two important questions. First, how many molecules or mechanisms are required for Treg to work? Second, how should we evaluate the contribution of any given Treg molecule/mechanism and how is this likely to relate (or not) to the phenotype seen in Scurfy/Foxp3-deficient mice? In this discussion piece, I will briefly outline our current understanding of the Treg arsenal and address these important questions.
Source: European Journal of Immunology
Author: Dario Vignali
Institution: St. Jude Children's Research Hospital
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2107972965