Work

Separation Anxiety: Detachment from the Extracellular Matrix Induces Metabolic Changes that Can Stimulate Tumorigenesis

Year: 2009

Type: article

Abstract: One of the earliest stages of tumor progression involves the ability of cells to survive and proliferate when not attached to the extracellular matrix (ECM). New research using a physiologically relevant breast cancer model reveals how separation from the ECM stimulates metabolic changes characteristic of developing tumors.

Source: Journal of Molecular Cell Biology

DOI: 10.1093/jmcb/mjp050

Authors: M. A. Cichon, D. C. Radisky

Institutions: Mayo Clinic in Florida, Mayo Clinic Comprehensive Cancer Center (Florida)

Language: English

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2108051925