Work

A Model of 3D Propagation in Discrete Cardiac Tissue.

Year: 2006

Type: article

Abstract: A model was developed of a bundle of cardiac fibers embedded in an extracellular space. In contrast to the classical bidomain approach, the model is constructed such that the intracellular and extracellular spaces are spatially distinct. The model was used to test the hypothesis that the distribution of the extracellular fluid in the tissue can affect the conduction velocity. The preliminary results suggest that under nominally normal conditions, the propagation speed depends on the fraction of extracellular space and less on the actual distribution of extracellular space within the bundle.

Source: PubMed

Authors: Jg Stinstra, Sf Roberts, Jb Pormann, Rs Macleod, Cs Henriquez

Institutions: University of Utah, Duke University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Center for Research Resources

Awards: Computational Tools for Multi-Scale Heart Modeling, Center for Integrative Biomedical Computing

OpenAlex ID: W2108092045

FWCI: 0.711

Cites: 4

Cited by: 21

Related to: 10