Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection
Year: 2002
Type: article
Abstract: Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.
Source: Journal of Virology
Authors: Todd M. Allen, Peicheng Jing, Briana Calore, Helen Horton, David H. O'Connor, Tomas Hanke, Marian Piekarczyk, Richard Ruddersdorf, Bianca R. Mothé, Carol Emerson, Nancy Wilson, Jeffrey D. Lifson, Igor M. Belyakov, Jay A. Berzofsky, Chenxi Wang, David B. Allison, David C. Montefiori, Ronald C. Desrosiers, Steven Wolinsky, Kevin J. Kunstman, John D. Altman, Alessandro Sette, Andrew J. McMichael, David I. Watkins
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: A Novel, Logical Approach to HIV Vaccine Development, G2069871934, A Novel, Logical Approach to HIV Vaccine Development, CTL-BASED VACCINES FOR THE AIDS VIRUS, G3029148, G4588529807, G486184614, G4879939293, GREAT LAKES REGIONAL CENTER FOR AIDS RESEARCH, G5845976086, OPERATIONS &TECHNICAL SUPPORT, G7007744452, G9000042849, G9000065652, G9000341891, Wisconsin National Primate Research Center Support
OpenAlex ID: W2108120872