Work

Morphogen Gradient Formation

Year: 2009

Type: preprint

Abstract: How morphogen gradients are formed in target tissues is a key question for understanding the mechanisms of morphological patterning. Here, we review different mechanisms of morphogen gradient formation from theoretical and experimental points of view. First, a simple, comprehensive overview of the underlying biophysical principles of several mechanisms of gradient formation is provided. We then discuss the advantages and limitations of different experimental approaches to gradient formation analysis.

Source: Cold Spring Harbor Perspectives in Biology

DOI: 10.1101/cshperspect.a001255

Authors: O. Wartlick, A. Kicheva, M. Gonzalez-Gaitan

Institution: University of Geneva

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2108173304

Cites: 88

Cited by: 307

Related to: 9