Work

A Redox‐Activated MRI Contrast Agent that Switches Between Paramagnetic and Diamagnetic States

Year: 2013

Type: article

Abstract: Trigger ready: A redox-activated MRI contrast agent can cycle between paramagnetic CoII (MRI-active) and diamagnetic CoIII (MRI-silent). The paramagnetic CoII form produces a highly shifted CEST signal at 135 ppm (37 °C). The redox state of the Co complex is altered by O2 partial pressure and reductant concentration (thiols) on a time scale relevant to imaging. MT=magnetization transfer.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201306394

Authors: Pavel B. Tsitovich, Joseph A. Spernyak, Janet R. Morrow

Institutions: University at Buffalo, State University of New York, Roswell Park Comprehensive Cancer Center

Language: English

Topic: Lanthanide and Transition Metal Complexes

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: green

Funders: U.S. Public Health Service, National Cancer Institute

Awards: G2436491713, G881394232, Roswell Park Cancer Center Support Grant, Iron paraCEST MRI Contrast Agents for Monitoring Tumor Acidosis