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Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages

Year: 2006
Type: article
Abstract: Apicomplexan protozoan pathogens avoid destruction and establish a replicative niche within host cells by forming a nonfusogenic parasitophorous vacuole (PV). Here we present evidence for lysosome-mediated degradation of Toxoplasma gondii after invasion of macrophages activated in vivo. Pathogen elimination was dependent on the interferon gamma inducible-p47 GTPase, IGTP, required PI3K activity, and was preceded by PV membrane indentation, vesiculation, disruption, and, surprisingly, stripping of the parasite plasma membrane. Denuded parasites were enveloped in autophagosome-like vacuoles, which ultimately fused with lysosomes. These observations outline a series of mechanisms used by effector cells to redirect the fate of a classically nonfusogenic intracellular pathogen toward a path of immune elimination.
DOI: 10.1084/jem.20061318
Authors: Yun M. Ling, Michael H. Shaw, Carol Ayala, Isabelle Coppens, Gregory A. Taylor, David J.P. Ferguson, George S. Yap
Institutions: Brown University, Rhode Island Hospital, Johns Hopkins University, Duke University, Duke Medical Center, John Radcliffe Hospital, University of Oxford
Language: English
Subfield: Parasitology
Open Access status: green
OpenAlex ID: W2108205859
FWCI: 21.94
Cites: 31
Cited by: 369
Related to: 10