Body Mass Index and Waist Circumference in Relation to Lung Cancer Risk in the Women's Health Initiative
Year: 2008
Type: article
Abstract: Investigators in several epidemiologic studies have observed an inverse association between body mass index (BMI) and lung cancer risk, while others have not. The authors used data from the Women's Health Initiative to study the association of anthropometric factors with lung cancer risk. Over 8 years of follow-up (1998-2006), 1,365 incident lung cancer cases were ascertained among 161,809 women. Cox proportional hazards models were used to estimate hazard ratios adjusted for covariates. Baseline BMI was inversely associated with lung cancer in current smokers (highest quintile vs. lowest: hazard ratio (HR) = 0.62, 95% confidence interval (CI): 0.42, 0.92). When BMI and waist circumference were mutually adjusted, BMI was inversely associated with lung cancer risk in both current smokers and former smokers (HR = 0.40 (95% CI: 0.22, 0.72) and HR = 0.61 (95% CI: 0.40, 0.94), respectively), and waist circumference was positively associated with risk (HR = 1.56 (95% CI: 0.91, 2.69) and HR = 1.50 (95% CI: 0.98, 2.31), respectively). In never smokers, height showed a borderline positive association with lung cancer. These findings suggest that in smokers, BMI is inversely associated with lung cancer risk and that waist circumference is positively associated with risk.
Source: American Journal of Epidemiology
DOI: 10.1093/aje/kwn109
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Women's Health Initiative, Brigham and Women's Hospital, Kaiser Permanente, Brown University, University of Miami, Wayne State University, Ohio State University, Emory University, Northwestern University, George Washington University, Wake Forest University, University of Minnesota, University of Cincinnati, University of Nevada, Reno, University of California, Los Angeles, University of California, Davis, University of North Carolina at Chapel Hill, University of California, San Diego, University of California, San Francisco, University at Buffalo, University of California, Irvine, National Heart, Lung, and Blood Institute
OpenAlex ID: W2108270116