Work

Making sense of how HIV kills infected CD4 T cells: implications for HIV cure

Year: 2014

Type: article

Abstract: Defining how HIV does, and does not, kill the host CD4 T cell that it infects is of paramount importance in an era when research is approaching a cure for infection. Three mutually exclusive pathways can lead to the death of HIV-infected cells during the HIV life cycle, before, coincident and after HIV integration and consequently may affect viral replication. We discuss the molecular mechanism underlying these pathways, the evidence supporting their roles in vivo, and contemplate how understanding these pathways might inform novel approaches to promote viral cure of HIV.

Source: Molecular and Cellular Therapies

DOI: 10.1186/2052-8426-2-20

Authors: Nathan W Cummins, Andrew D Badley

Institution: Mayo Clinic

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Center for Advancing Translational Sciences