Work

An endosomal beta COP is involved in the pH-dependent formation of transport vesicles destined for late endosomes.

Year: 1996

Type: article

Abstract: In this paper, we show that beta COP is present on endosomes and is required for the formation of vesicles which mediate transport from early to late endosomes. Both the association of beta COP to endosomal membranes as well as transport vesicle formation depend on the lumenal pH. We find that epsilon COP, but not gamma COP, is also associated to endosomes, and that this association is also lumenal pH dependent. Our data, thus, indicate that a subset of COPs is part of the mechanism regulating endosomal membrane transport, and that membrane association of these COPs is controlled by the acidic properties of early endosomes, presumably via a trans-membrane pH sensor.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.133.1.29

Authors: F Aniento, F Gu, R G Parton, J Gruenberg

Institution: University of Geneva

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Award: Regulation of endocytic membrane traffic