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Positive Correlation between Epstein-Barr Virus Viral Load and Anti-Viral Capsid Immunoglobulin G Titers Determined for Hodgkin's Lymphoma Patients and Their Relatives

Year: 2006
Type: article
Study design: Observational Study
Abstract: Markers of Epstein-Barr virus (EBV) infection include measures of specific serological titers and of viral load (VLo) in peripheral blood mononuclear cells. Few studies have investigated the correlation between these two phenotypes. Here, we found that there was no correlation between VLo and either anti-EBV nuclear antigen type 1 or anti-early antigen immunoglobulin G (IgG) titer but that anti-viral capsid antigen (VCA) IgG titer increased with VLo in peripheral blood mononuclear cells in patients with Hodgkin's lymphoma (P = 3.10(-3)). A similar pattern was observed in healthy first-degree relatives (parents and siblings) of patients (P = 6.10(-4)). Our results indicate that anti-VCA IgG titers and EBV VLo are specifically correlated EBV phenotypes.
DOI: 10.1128/jcm.44.1.47-50.2006
Authors: Caroline Besson, Corinne Amiel, Catherine Le-Pendeven, Pauline Brice, Christophe Fermé, Patrice Carde, Olivier Hermine, Martine Raphael, Laurent Abel, Jean-Claude Nicolas
Institutions: Inserm, Université Paris Cité, Human Genetic of Infectious Diseases, Bicêtre Hospital, Université Paris Descartes, Hôpital Tenon, Hôpital Saint-Louis, Institut Gustave Roussy, Hôpital Necker-Enfants Malades, Assistance Publique – Hôpitaux de Paris
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: green
Funders: Institut National de la Santé et de la Recherche Médicale, BNP Paribas Cardif, Ligue Contre le Cancer, Fondation de France, Vlaamse regering, Fondation BNP Paribas
OpenAlex ID: W2108311858
FWCI: 1.739
Cites: 19
Cited by: 35
Related to: 10