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Neuraminidase Is Important for the Initiation of Influenza Virus Infection in Human Airway Epithelium

Year: 2004

Type: article

Abstract: Influenza virus neuraminidase (NA) plays an essential role in release and spread of progeny virions, following the intracellular viral replication cycle. To test whether NA could also facilitate virus entry into cell, we infected cultures of human airway epithelium with human and avian influenza viruses in the presence of the NA inhibitor oseltamivir carboxylate. Twenty- to 500-fold less cells became infected in drug-treated versus nontreated cultures (P < 0.0001) 7 h after virus application, indicating that the drug suppressed the initiation of infection. These data demonstrate that viral NA plays a role early in infection, and they provide further rationale for the prophylactic use of NA inhibitors.

Source: Journal of Virology

DOI: 10.1128/jvi.78.22.12665-12667.2004

Authors: Mikhail N. Matrosovich, Tatyana Y. Matrosovich, Thomas Gray, Noel A. Roberts, Hans-Dieter Klenk

Institutions: Philipps University of Marburg, Chumakov Institute of Poliomyelitis and Viral Encephalitides, National Institutes of Health, National Institute of Environmental Health Sciences, Roche (United Kingdom)

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2108358599

FWCI: 10.22

Cites: 12

Cited by: 607

Related to: 10