Year: 2012
Type: article
Study design: Observational Study
Abstract: Psoriasis is a hyper-proliferative disease of the skin in which immunological mechanisms play a direct pathogenetic role. There have been limited studies of natural killer (NK) cells in psoriasis. The aim of this study was to examine the phenotype of NK cells in skin biopsies and peripheral blood mononuclear cells from patients with psoriasis and healthy controls. CD56(+) CD16(-) and CD56(+) CD16(+) NK cells were isolated from lesional skin, unaffected skin and PBMC of psoriasis patients, and normal skin and PBMC from healthy controls. The expression of CD57, NKG2A and NKG2C was assessed by flow cytometry. NK cells in psoriasis skin lesions were skewed in their expression of CD57, a marker of NK cell maturity, with CD57 expression significantly reduced and NKG2A expression increased on NK cells in lesional and unaffected skin compared to controls. These data suggest that in this patient cohort, NK cells could be isolated from psoriasis lesions and exhibit an immature phenotype.
Source: Experimental Dermatology
DOI: 10.1111/exd.12060
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: Institute of Translational Health Sciences, Fundação de Amparo à Pesquisa do Estado de São Paulo, International AIDS Society, National Institutes of Health, University of California, San Francisco, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Awards: G2182764755, NK Memory, Human Natural Killer Cell Biology, Cellular immune responses in infectious diseases and primary immunodeficiencies, Genetic Analysis of the TNF Pathway in Psoriasis, Prospective analysis of the virological and immunological characteristics in individuals with recent HIV-1 infection in the cities of São Paulo and Santos, Diabetes Research Center, G87331943, Multidisciplinary Training Program in Lung Disease
OpenAlex ID: W2108380253