Year: 2011
Type: review
Abstract: SUMMARY: Src is believed to play an important role in cancer, and several agents targeting Src are in clinical development. DESIGN: We reviewed Src structure and function and preclinical data supporting its role in the development of cancer via a PubMed search. We conducted an extensive review of Src inhibitors by searching abstracts from major oncology meeting databases in the last 3 years and by comprehensively reviewing ongoing clinical trials on ClinicalTrials.gov. RESULTS: In this manuscript, we briefly review Src structure and function, mechanisms involving Src that lead to the development of cancer, and Src inhibitors and key preclinical data establishing a rationale for clinical application. We then focus on clinical data supporting their use in solid tumor malignancies, a newer arena than their more well-established hematologic applications. Particularly highlighted are clinical trials investigating new biomarkers as well as ongoing studies assessing Src inhibitor activity in biomarker-selected patient populations. We also review newer investigational Src-targeting agents. CONCLUSIONS: Src inhibitors have shown little activity in monotherapy trials in unselected solid tumor patient populations. Combination studies and biomarker-driven clinical trials are under way.
Source: The Oncologist
Institutions: University of Colorado Cancer Center, Mayo Clinic
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: bronze
Funders: Pfizer, AstraZeneca, Genentech
OpenAlex ID: W2108426094