Work

Reduced Intensity Conditioning (RIC) is Associated with a Significant Decrease In Day +100 Non-Relapse Mortality (NRM), Grade II-IV AGVHD and Overall Survival (OS) In Pediatric Recipients Following Cord Blood Transplantation (CBT)

Year: 2009

Type: article

Abstract: We and others have demonstrated that myeloablative conditioning (MAC) and CBT results in a high engraftment rate and lower severe AGVHD rate but a 20–40% incidence of Day +100 NRM (Cairo et al BBMT, 2008). RIC and AlloSCT in adults have been associated with a decrease in acute toxicity and NRM (Satwani/Cairo et al BBMT, 2005). Our group recently demonstrated the safety and sustained high donor chimerism following RIC and UCBT in pediatric recipients (Bradley/Cairo et al BMT, 2007). In this study we investigated the risk factors associated with Day +100 NRM, Grade II-IV AGVHD and OS in 101 consecutive CBT pediatric recipients.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2008.12.238