Work

Molecular and biologic markers of progression in monoclonal gammopathy of undetermined significance to multiple myeloma

Year: 2010

Type: review

Abstract: Multiple myeloma (MM) is a malignant plasma cell dyscrasia localized in the bone marrow. Recent studies have shown that MM is preceded in virtually all cases by a premalignant state called monoclonal gammopathy of undetermined significance (MGUS). This review focuses on non-IgM MGUS and its progression to MM. Although certain clinical markers of MGUS progression have been identified, it currently is not possible to accurately determine individual risk of progression. This review focuses on the various biologic and molecular markers that could be used to determine the risk of MM progression. A better understanding of the pathogenesis will allow us to define the biological high-risk precursor disease and, ultimately, to develop early intervention strategies designed to delay and prevent full-blown MM.

Source: Leukemia & lymphoma/Leukemia and lymphoma

DOI: 10.3109/10428194.2010.525725

Authors: Sham Mailankody, Esther Mena, Constance M. Yuan, Arun Balakumaran, W. Michael Kuehl, Ola Landgren

Institutions: National Institutes of Health, National Cancer Institute, Center for Cancer Research, National Institute of Dental and Craniofacial Research

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute