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Human Transcriptome and Chromatin Modifications: An ENCODE Perspective

Year: 2013

Type: article

Abstract: A decade-long project, led by several international research groups, called the Encyclopedia of DNA Elements (ENCODE), recently released an unprecedented amount of data. The ambitious project covers transcriptome, cistrome, epigenome, and interactome data from more than 1,600 sets of experiments in human. To make use of this valuable resource, it is important to understand the information it represents and the techniques that were used to generate these data. In this review, we introduce the data that ENCODE generated, summarize the observations from the data analysis, and revisit a computational approach that ENCODE used to predict gene expression, with a focus on the human transcriptome and its association with chromatin modifications.

Source: Genomics & Informatics

DOI: 10.5808/gi.2013.11.2.60

Authors: Li Shen, Inchan Choi, Eric J. Nestler, Kyoung-Jae Won

Institutions: Icahn School of Medicine at Mount Sinai, University of Pennsylvania

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,290

Funders: National Institute of Mental Health, National Institute on Drug Abuse