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Characterization of a Mycobacterium smegmatis Mutant That Is Simultaneously Resistant to d -Cycloserine and Vancomycin

Year: 2000
Type: article
Abstract: A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.
DOI: 10.1128/aac.44.6.1701-1704.2000
Authors: Marcy Peteroy, Anatoly Severin, Frances Zhao, Dalya Rosner, Uri Lopatin, Hataichanouk Scherman, Aimee Belanger, Bohdan Harvey, Graham F. Hatfull, Patrick J. Brennan, Nancy D. Connell
Language: English
Field: Medicine
Open Access status: green
OpenAlex ID: W2108905802
FWCI: 0.521
Cites: 17
Cited by: 20
Related to: 10