Antipsychotic drug-induced weight gain mediated by histamine H 1 receptor-linked activation of hypothalamic AMP-kinase

Year: 2007

Type: article

Abstract: The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We report that orexigenic AAPDs potently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of histamine H1 receptors. These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.0611417104

Authors: Sangwon F. Kim, Alex S. Huang, Adele M. Snowman, Cory Teuscher, Solomon H. Snyder

Institutions: University of Vermont, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Regulation of Appetite and Obesity

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Multiple Sclerosis Society, National Institutes of Health, U.S. Public Health Service, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke

OpenAlex ID: W2108988641