A Prospective Randomized Study of Chop Versus Chop Plus Alpha-2B Interferon in Patients with Intermediate and High Grade Non-Hodgkin's Lymphoma: The International Oncology Study Group NHL1 Study
Year: 2000
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: UNLABELLED: The addition of a brief alpha interferon regimen to each CHOP induction cycle, plus one year of alpha interferon thrice weekly maintenance therapy, has no early effect on response rates or survival in patients with Intermediate or High grade cell NHL. BACKGROUND: The CHOP (Cyclophosphamide, Adriamycin. Vincristine, Prednisone) regimen is the most widely used first-line therapy for patients with Intermediate or High Grade (IG/HG) non-Hodgkin's lymphoma (NHL). Alpha 2b interferon (INF) enhances response rates and improves survival in low-grade NHL. The International Oncology Study Group (IOSG) conducted a prospective randomized study comparing CHOP alone or combined with INF in patients with IG/HG-NHL. The primary study aim was to compare the objective response rates in these patient cohorts. PATIENTS AND METHODS: Patients with a confirmed diagnosis of measurable NHL of International Working Formulation (IWF) groups D to H histology were randomized to receive CHOP alone or CHOP with 5Mu INF s.c. for 5 days on days 22 to 26 of each 28 day cycle with INF 5 million units (Mu) given three times per week subcutaneously for 52 weeks in those patients who responded to CHOP plus INF. RESULTS: The overall response rates were equivalent in both groups: CHOP alone (214 patients) 81% (complete 55%, partial 26%); CHOP plus INF (221 patients) 80% (complete 54%, partial 26%). At 36 months, the actuarial survival rate was equivalent in both groups. CONCLUSIONS: There is no apparent early advantage in terms of response or survival conferred by adding the study INF regimen to CHOP therapy for patients with IG/HG-NHL.
Authors: Francis J. Giles, Jianqin Shan, Suresh H. Advani, Hamdi Akan, Zeba Aziz, Hamdy A. Azim, P. P. Bapsy, Filiz Buyukkececi, Boonsoom Chaimongkol, Soon-Keng Cheong, Reda Hamza, Hussein M. Khalid, Tanin Intragumtornchai, Sang W. Kim, Sam Y. Kim, Haluk Koc, Lalit Kumar, Ravi Kumar, Kenny I. Lei, Arnuparp Lekhakula, Abdul Muthalib, Moosa Patel, Viz P. Poovalingam, Wichai Prayoonwiwat, Fauzia Rana, Arryanto H. Reksodiputro, Paul Ruff, T. G. Sagar, Andrew P. Schwarera, Catherine Suharti, Iman Supindiman, Goh Y. Tee, Taratorn Thamprasit, Antonio H. Villalon, Nicholas R. Wickham, John E. Wong, Attila Yalcin
Institutions: Tata Memorial Hospital, Ankara University, Allama Iqbal Medical College, Cairo University, Cairo University hospitals, Kidwai Memorial Institute of Oncology, Ege University, Chiang Mai University, National University of Malaysia, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Asan Medical Center, Chungnam National University Hospital, DR. B.R.A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Prince of Wales Hospital, Prince of Songkla University, Dharmais Cancer Hospital, Chris Hani Baragwanath Hospital, Phramongkutklao College of Medicine, Shaukat Khanum Memorial Cancer Hospital and Research Center, Cancer Institute (WIA), The Alfred Hospital, Dr. Kariadi Hospital, Dr. Hasan Sadikin General Hospital, Padjadjaran University, Singapore General Hospital, University of the Philippines Manila, Queen Elizabeth Hospital, National University Hospital, Mahidol University, Ramathibodi Hospital
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: National Cancer Institute
OpenAlex ID: W2109034081