Work

Transient Viral DNA Replication and Repression of Viral Transcription Are Supported by the C-Terminal Domain of the Bovine Papillomavirus Type 1 E1 Protein

Year: 1998

Type: article

Abstract: The bovine papillomavirus type 1 E1 protein is important for viral DNA replication and transcriptional repression. It has been proposed that the full-length E1 protein consists of a small N-terminal and a larger C-terminal domain. In this study, it is shown that an E1 polypeptide containing residues 132 to 605 (which represents the C-terminal domain) is able to support transient viral DNA replication, although at a level lower than that supported by the wild-type protein. This domain can also repress E2-mediated transactivation from the P89 promoter as well as the wild-type E1 protein can.

Source: Journal of Virology

DOI: 10.1128/jvi.72.1.796-801.1998

Authors: Maureen C. Ferran, Alison A. McBride

Institutions: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

OpenAlex ID: W2109137261

FWCI: 2.333

Cites: 38

Cited by: 22

Related to: 10