Work

Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1

Year: 2011

Type: article

Abstract: Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how PARP1 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0023548

Authors: Xiangduo Kong, Jared Stephens, Alexander R. Ball, Jason T. Heale, Daniel A. Newkirk, Michael W. Berns, Kyoko Yokomori

Institution: University of California, Irvine

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,382

Funders: National Institutes of Health, National Cancer Institute, National Institute of Environmental Health Sciences, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Air Force Office of Scientific Research

Awards: G1523888516, G2156078568, Molecular mechanism of DNA damage recognition in mammals, G3640713170, G411368755, A Laser Microbeam Biotechnology Resource, G6296288502, Role of Human Condensin in DNA repair, Training Program in Systems Biology of Development, G9000199918, Cancer Center Support Grant, G921069283

OpenAlex ID: W2109176489

FWCI: 1.17

Cites: 26

Cited by: 35

Related to: 10