Work

In vivo bioluminescence imaging of acute promyelocytic leukemia cell trafficking and mobilization by AMD3100

Year: 2006

Type: article

Abstract: Novel approaches have been developed to mobilize hematopoietic stem cells (HSC) for patients undergoing autologous and allo transplantation. These strategies may provide insights into improved HSC collection and enhanced egress of leukemic cells and thus sensitivity to anti-leukemia therapy. CXCR4/SDF-1 axis regulates the trafficking of normal HSC to and from the bone marrow (BM). AMD3100 (AMD) specifically and reversibly blocks SDF-1 binding to CXCR4, and is a promising mobilizing agent currently in clinical development.

Source: Transplantation and Cellular Therapy

DOI: 10.1016/j.bbmt.2005.11.059

Authors: B. Nervi, M. Holt, M.P. Rettig, G. Bridger, T.J. Ley, J.F. DiPersio

Institution: Washington University in St. Louis

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,650