Work

Photoreversible Patterning of Biomolecules within Click‐Based Hydrogels

Year: 2011

Type: article

Abstract: Lighting the way: Biochemical cues have been reversibly patterned into hydrogels with full spatiotemporal control by using two photochemical reactions. The hydrogel is conjugated with a peptide by a thiol-ene photoaddition reaction that is initiated by visible light. Subsequent, selective photocleavage of an o-nitrobenzyl ether with UV light enables dynamic presentation of the peptide to cells with control in three dimensions.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201106463

Authors: Cole A. DeForest, Kristi S. Anseth

Institutions: Howard Hughes Medical Institute, University of Colorado Boulder

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: National Science Foundation, Howard Hughes Medical Institute

Award: Spatiotemporal Regulated Click Hydrogels for 3D Cell Culture