Work

Bidirectional synaptic plasticity: from theory to reality

Year: 2003

Type: review

Abstract: Theories of receptive field plasticity and information storage make specific assumptions for how synapses are modified. I give a personal account of how testing the validity of these assumptions eventually led to a detailed understanding of long-term depression and metaplasticity in hippocampal area CA1 and the visual cortex. The knowledge of these molecular mechanisms now promises to reveal when and how sensory experience modifies synapses in the cerebral cortex.

Source: Philosophical Transactions of the Royal Society B Biological Sciences

DOI: 10.1098/rstb.2002.1255

Author: Mark F. Bear

Institutions: Howard Hughes Medical Institute, Brown University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2109372640

FWCI: 1.072

Cites: 47

Cited by: 264

Related to: 10