Work

Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications

Year: 2012

Type: article

Abstract: The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.

Source: Current Protein and Peptide Science

DOI: 10.2174/138920312804871193

Authors: Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek, Barbara Maciejewska, Anne-Sophie Delattre, Rob Lavigne

Institutions: University of Wrocław, KU Leuven

Language: English

Topic: Bacteriophages and microbial interactions

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2109442030

FWCI: 2.621

Cites: 260

Cited by: 277

Related to: 10